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U.S. overdose deaths fell nearly 14% in 2025
CDC’s provisional estimate fell to 69,973; opioid-involved deaths also declined.
Event / data period: 2026-05-13
Published: · Updated:
IllustrationCDC estimated 69,973 overdose deaths in 2025, compared with 81,313 in 2024.
Opioid-involved deaths fell to 44,564. Data are provisional and exclude Puerto Rico from the national total.
Data
U.S. provisional overdose indicators
CDC/NCHS provisional national overdose death estimates.
- Estimated overdose deaths
- 69,973 deaths
- 2025 · Estimate
- Prior-year overdose estimate
- 81,313 deaths
- 2024 · Estimate
- Estimated opioid-involved deaths
- 44,564 deaths
- 2025 · Estimate
Methodology
CDC/NCHS provisional estimates; Puerto Rico is excluded from the U.S. total.
Updated: