# AWS outlines a genomic workflow for querying resistance genes

> An AWS reference architecture dated October 12 processes public sequencing reads from NCBI SRA with HealthOmics and makes resistance-gene results queryable in natural language. It is a demonstration architecture, not new surveillance data or a clinical system.

- Canonical URL: https://newsverum.com/en/news/aws-agentic-amr-surveillance-reference-architecture-2026
- Publisher: Newsverum
- Section: Technology
- Published: 2026-10-15T22:00:39+00:00
- Updated: 2026-10-15T22:00:39+00:00
- Source review period: 2026-10-12
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AWS published a reference architecture that takes publicly available sequencing reads from the NCBI Sequence Read Archive (SRA) through download, quality control, genome assembly and resistance-gene screening. The workflow uses fastp, SKESA and AMRFinderPlus on HealthOmics; results are normalized to the hAMRonization schema and stored in S3 Tables/Iceberg.

A Strands agent queries those tables through Amazon Athena so researchers can ask in natural language about resistance-gene profiles and trends; answers are required to include gene identifiers, the detecting tool and confidence values from the underlying data. AWS says this is a demonstration architecture deployable with CDK, not a customer deployment or clinical system; the post reports no new epidemiological findings.

## Data

### AWS outlines a genomic workflow for querying resistance genes

Methodology: Claims and technical details are attributed to the cited primary source; this is not independent testing.

| date | label | description | status |
|---|---|---|---|
| 2026-10-12 | Source publication date | An AWS reference architecture dated October 12 processes public sequencing reads from NCBI SRA with HealthOmics and makes resistance-gene results queryable in natural language. It is a demonstration architecture, not new surveillance data or a clinical system. | occurred |

Sources: <https://aws.amazon.com/blogs/architecture/agentic-antimicrobial-resistance-surveillance-with-aws-healthomics-and-amazon-bedrock-agentcore/> · Download data: [JSON](https://newsverum.com/api/v1/articles/aws-agentic-amr-surveillance-reference-architecture-2026/data/reported-event?lang=en&format=json) · [CSV](https://newsverum.com/api/v1/articles/aws-agentic-amr-surveillance-reference-architecture-2026/data/reported-event?lang=en&format=csv)

## Sources

- [AWS Architecture Blog](<https://aws.amazon.com/blogs/architecture/agentic-antimicrobial-resistance-surveillance-with-aws-healthomics-and-amazon-bedrock-agentcore/>) (Source checked: 2026-10-15; Published: 2026-10-12)

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